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It suddenly seemed like a lightbulb went on in her head, and she began picking up one sign after another. And soon we noticed she was even combining them into little sentences. An air plane or something would disappear, and she d excitedly sign airplane all done. It was so great! Mother of fifteen-month-old Laney

Autosomal recessive or dominant X-linked (CAG repeat expansion), less often autosomal dominant Autosomal recessive, rarely dominant

J Neurosurg 21:385, 1964 BURKE D, LANCE JW: Myotatic unit and its disorders, in Asbury AK, McKhann GM, McDonald WI (eds): Diseases of the Nervous System: Clinical Neurobiology, 2nd ed Philadelphia, Saunders, chap 20, pp 270 284 DAVIDOFF RA: Antispasticity drugs: Mechanisms of action Ann Neurol 17:107, 1985 DAVIDOFF RA: Skeletal muscle tone and the misunderstood stretch re ex Neurology 42:951, 1992 DENNY-BROWN D: The Cerebral Control of Movement Spring eld, IL, Charles C Thomas, 1966 DENNY-BROWN D: The nature of apraxia J Nerv Ment Dis 12:9, 1958 EVARTS EV, SHINODA Y, WISE SP: Neurophysiological Approaches to Higher Brain Functions New York, Wiley, 1984 FAGLIONI PR, BASSO A: Historical perspectives on neuroanatomical correlates of limb apraxia, in Roy EA (ed): Neuropsychological Studies of Apraxia and Related Disorders Amsterdam, North Holland, 1985, pp 3 44 FEINBERG TE, SCHINDLER RJ, FLANAGAN NG, HABER LD: Two alien hand syndromes Neurology 42:19, 1992.

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FULTON JF: Physiology of the Nervous System New York, Oxford University Press, 1938, chap 20 FULTON JF, KELLER AD: The Sign of Babinski A Study in the Evolution of Cortical Dominance in Primates Charles C Thomas, Spring eld, 1932 GESCHWIND N: The apraxias: Neural mechanisms of disorders of learned movement Am Sci 63:188, 1975 GILMAN S, MARCO LA: Effects of medullary pyramidotomy in the monkey Brain 94:495, 515, 1971 HALLETT M, SHAHANI BT, YOUNG RR: EMG analysis of stereotyped voluntary movements in man J Neurol Neurosurg Psychiatry 38:1154, 1975 HENNEMAN E: Organization of the spinal cord and its re exes, in Mountcastle VB (ed): Medical Physiology, 14th ed Vol 1 St Louis, Mosby, 1980, pp 762 786 IWATSUBO T, KUZUHARA S, KANEMITSU A, et al: Corticofugal projections to the motor nuclei of the brain stem and spinal cord in humans Neurology 40:309, 1990.

KERTESZ A, FERRO JM, SHEWAN CM: Apraxia and aphasia: The functional anatomical basis for their dissociation Neurology 34:40, 1984 LANCE JW: The control of muscle tone, re exes and movement: Robert Wartenburg Lecture Neurology 30:1303, 1980 LAPLANE D, TALAIRACH J, MEININGER V, et al: Motor consequences of motor area ablations in man J Neurol Sci 31:29, 1977 LASSEK AM: The Pyramidal Tract Spring eld, IL, Charles C Thomas, 1954 LAWRENCE DG, KUYPERS HGJM: The functional organization of the motor system in the monkey Brain 91:1, 15, 1968 LIEPMANN H: Das Krankheitsbild der Apraxie (motorische Asymbolie auf Grund eines Falles von einseitiger Apraxie) Monatsschr Psychiatry Neurol 8:15, 102, 182, 1900 LORENTE DE NO R: Cerebral cortex: Architecture, intracortical connections, motor projections, in Fulton JF (ed): Physiology of the Nervous System, 3rd ed New York, Oxford University Press, 1949, pp 288 330 LURIA AR: The Working Brain: An Introduction to Neuropsychology.

New York, Basic Books, 1973 MOUNTCASTLE VB: Central nervous mechanisms in sensation, in Mountcastle VB (ed): Medical Physiology, 14th ed Vol 1: Part 5 St Louis, Mosby, 1980, chaps 11 19, pp 327 605 NATHAN PW, SMITH M, DEACON P: Vestibulospinal, reticulospinal and descending propriospinal nerve bers in man Brain 119:1809, 1996 NYBERG-HANSEN R, RINVIK E: Some comments on the pyramidal tract with special reference to its individual variations in man Acta Neurol Scand 39:1, 1963 PANTANO P, FORMISANO R, RICCI M, et al: Prolonged muscular accidity after stroke Morphological and functional brain alterations Brain 118: 1329, 1995 PAUSE M, KUNESCH F, BINKOFSKI F, FREUND H-J: Sensorimotor disturbances in patients with lesions of the parietal cortex Brain 112:1599, 1989..

F|GURE 17.19 A continuous of F(x)cos[d(r)]versus plot posilion theseven with discrete points to develop used

1. Here are the two equations in their original forms: 3x + y 1 = 0 and 2x 2 y + 1 = 0 We can morph these to obtain the following functions of x: y = 3x + 1 and y = 2x 2 + 1 When we mix the right sides of these equations, we obtain 3x + 1 = 2x 2 + 1 which morphs into the quadratic equation 2x 2 + 3x = 0

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